Assessment of TRAb Level in Sera of Patients with Graves' Disease

ISBN-13: 9786200697189 / Angielski / Miękka / 2025 / 132 str.

Zainab Razaq Kareem; Fatin Fadhel Al-Kazazz; Ahmed Mahdi Rheima

Opis

Graves' disease (GD) is the leading cause of autoimmune hyperthyroidism, characterized by the presence of thyroid stimulating hormone receptor antibodies (TRAb). These autoantibodies play a crucial role in the pathogenesis of the disease and represent a highly specific diagnostic biomarker.This book presents a comprehensive assessment of TRAb levels in patients with Graves' disease (GD), highlighting their diagnostic significance and correlations with hormonal and inflammatory markers such as interleukin-6 (IL-6). The work distinguishes between autoimmune and non-autoimmune hyperthyroidism,In addition to the clinical investigation, an innovative diagnostic approach was developed through a platinum nanoparticle (PtNP)-based nano-sandwich ELISA for thyroid stimulating hormone (TSH) detection. The integration of nanotechnology significantly improved the assay's sensitivity, demonstrating the potential of PtNPs as enhancers in immunodiagnostic applications.By combining biochemical, immunological, and nanotechnological perspectives, in this book offers an original contribution to the understanding and diagnosis of Graves' disease (GD).