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A wide-ranging review of the SeV vector, a multipurpose cytoplasmic RNA vector with extremely high performance, this volume covers diverse potent applications, including its use as an AIDS vaccine vector and the creation of BioKnife for tumor resection.

Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and...