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The significance of bone morphogenetic protein
activity in vivo is the induction of new bone. BMPs
were identified as proteins that regulate a wide
range of functions, such as proliferation,
differentiation and apoptosis of many different
types of cells, such as osteoblasts, epithelial
cells, neurons and immune cells. BMP signaling
pathway is regulated by Smad proteins, which include
Smad6 that has the ability to inhibit the BMP
pathway. This is of particular of interest in gene
therapy whereby regulation of Smad6 expression using
catalytic RNA might be able to stimulate...