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Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction. Numerous non-protein-coding genes are recently found to encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded 17 25 nucleotide RNAs capable of interfering with intracellular messenger RNAs (mRNAs) that contain either complete or partial complementarity, are useful for the design of new...

Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction. Numerous non-protein-coding genes are recently found to encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded 17 25 nucleotide RNAs capable of interfering with intracellular messenger RNAs (mRNAs) that contain either complete or partial complementarity, are useful for the design of new...

Extensive studies have been conducted on the identification, biogenesis, and processing of microRNA (miRNA) as well as research on the exact mechanism by which miRNAs bring about translational silencing of their targets. In addition, numerous publications point to an important role of miRNAs in development, reprogramming, epigenetics, pathogenesis of cancer, oncogenes and tumor suppressors, biomarkers of various disease onset, and regulation of adipogenesis and obesity; yet many questions still remain. In MicroRNA Protocols, Second Edition, experts in the field provide up-to-date...

"Autumn wind, autumn rain, fill my heart with sorrow"--these were the last words of Qiu Jin (1875-1907), written before she was beheaded for plotting to overthrow the Qing empire. Eventually, she would be celebrated as a Republican martyr and China's first feminist, her last words committed to memory by schoolchildren. Yet during her lifetime she was often seen as eccentric, even deviant; in her death, and still more in the forced abandonment of her remains, the authorities had wanted her to disappear into historical oblivion.

Burying Autumn tells the story of the enduring...

This book, to reflect the system’s diverse, relevant characteristics, uses three different mathematical tools, namely probability theory, fuzzy theory and random fuzzy theory, to model and analyze the reliability of each system. Reliability system engineering is an interdisciplinary area that chiefly focuses on the lifecycle characteristics of products and involves many fields of basic mathematics, technical science and management science. In recent years, there have been many books on reliability theory, but comparatively few on the reliability of mathematical models, or the...