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The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in...

Addresses microbially derived commercially important bioactive products that are currently or soon-to-be available. This second edition includes analyses of the use of recombinant enzymes to produce biologically active molecules; insights into the biochemistry, molecular biology and production of antibiotics used as therapeutic agents; and a focuses of state-of-the art techniques for the development of new antibiotics using novel approaches and strategies.