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This detailed biography offers a reappraisal of the career of Robert Curthose, William the Conqueror's eldest son and duke of Normandy from 1087 to 1106, locating the duke's career in the social, cultural and political context of the period. Robert's relationship with members of his family shaped the political landscape of England and Normandy for much of the late eleventh and early twelfth centuries: indeed, even after his incarceration, from 1106 to 1134, his son William Clito (d. 1128) continued the fight against Robert's brother, Henry I. Twice driven into exile, Robert defeated his...

North-east England experienced the Norman Conquest rather differently from the south of the country. This account of events in Northumbria gives an important alternative view of the Conquest and settlement, distinct from the more usual southern and court-centred evidence. A key factor in events was the monastic community of St Cuthbert in Durham, which had survived the political upheavals following the collapse of the Northumbrian kingdom under Scandinavian pressure in the ninth century. Its position thus strengthened, it occupied an influential place in the factors ranged against the...

The endothelium, the cell layer that forms the inner lining of blood vessels, is a spatially distributed system that extends to all reaches of the human body. Today, clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. Indeed, the endothelium has remarkable, though largely untapped, diagnostic and therapeutic potential. This volume endeavors to bridge the bench-to-bedside gap in endothelial biomedicine, with...

This reference serves as the first source to gather current data from endothelial cell biologists in various disciplines to summarize recent progress in the field-providing a complete understanding of the endothelium in health and disease and demonstrating its potential as a therapeutic target.