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viewed as rolling downhili from an uphill or This book represents an edited compilation of the scientific presentations given at an Interna- high-energy state. This transition results from tional Symposium on the Physiology of Diastole the opening of membrane pores that allow in Health and Disease, September 11 to 14, calcium to rush into the cytosol, triggering 1986, in Cambridge, Massachusetts. Numerous excitation-contraction coupling. If the energy studies have documented the importance of available to sarcoplasmic reticular and sarcolem- diastolic dysfunction in clinical heart disease. In...

In these memoirs, Braz Cubas, a wealthy nineteenth-century Brazilian, examines (from beyond the grave) his rather undistinguished life in 160 short chapters that are filled with philosophical digressions and exuberant insights. A clear forerunner of Gabriel Garcia Marquez and Jorge Luis Borges, Epitaph for a Small Winner, first published in 1880, is one of the wittiest self-portraits in literary history as well as "one of the masterpieces of Brazilian literature" (Salman Rushdie).