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Choosing the right man is never an exact science. For Claire Donahue, the feisty, logic-loving chemist with the ever-changing hair color, analyzing the details of her relationships is second nature. After a short and unheard of dry spell in her dating life, Claire finds plenty to analyze when three very different men begin vying for her attention. But when she starts looking for a long term commitment, and her relationship with each man deepens, will her constant studying of the facts give her clarity or just end up driving her crazy?

For better or for worse always comes before "I do." Jen appears to be in a picture perfect relationship. Claire seems to have found lasting chemistry. Just as the roommates' love lives start looking up, all other areas begin to fall apart. Adversities invade their days in the form of other women, career stress, and even death, all taking their toll. Now it's a question of whether or not their relationships are strong enough to endure. Will Claire and Jen hear wedding bells, or will they lose their chances at happily ever after?