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Topics in Vaccine Adjuvant Research provides a concise, focused review of the immunological basis of adjuvant activity. The first section of the book contains several chapters that discuss key issues in cellular immunology, such as antigen processing and presentation, cytokine regulation of immune responses, and mucosal immunology. The second section consists of brief chapters on the mechanism of action of several adjuvants, including IL-2, nonionic block polymers, and cholera toxin. The major goals of this book are to define what is known about the mechanisms of adjuvant activity, show how...

The HIV/AIDS pandemic is the most devastating global public health crisis since the great plagues of the Middle Ages, with more than 14,000 new HIV infections and 8,000 deaths due to AIDS every day. Although successful vaccines have been developed for most common childhood diseases, the development of a vaccine against the AIDS virus is a much greater challenge. More than 20 years after the discovery of the virus, the goal of a licensed and globally accessible vaccine is still several years away. AIDS Vaccine Development reviews the scientific challenges that have impeded the search for an...