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Current top-news in cardiovascular research includes the contribution of biomarkers and genetics in coronary artery diseases. Acute coronary syndrome and stable coronary artery disease are two clinical conditions arising from a spectrum of the same disease. This study was conducted to compare various natural haemostatic markers and some prothrombotic genes between the two clinical conditions. Some clinical data of the patients were also included. The study found a significant difference in the biological behaviour of prothrombotic activities during acute and stable conditions. All the...

Aspirin is the most commonly prescribed drug and the most cost effective therapy. However treatment failure has been of great concern in clinical practice. In the laboratory, assessment of platelet responsiveness to aspirin is not required routinely but due to some clinical reasons the test is indicated. It is important for the laboratory to have the appropriate procedure to perform the test as well as to interpret the results. Whole blood platelet aggregation method with conventional platelet aggregometer is able to detect the aspirin resistance state and it is less laborious than using...

Von Willebrand s disease (vWD) is the most common inherited bleeding disorder, found in approximately 1% of the general population. It is due to qualitative or quantitative defect of von Willebrand factor (vWF) causing impairment in the primary haemostasis. The main objective of this study was to detect vWD in Malay women with menorrhagia by using a panel of haemostatic profiles. A cross sectional study was conducted in gynecology clinic for the investigation of the unknown cause of menorrhagia. A panel of haemostatic profiles consisting platelet counts, activated partial thromboplastin time...

Diagnosis of Antiphospholipid syndrome (APS) depends on laboratory findings, such as detection of Lupus Anticoagulant (LAC) and anticardiolipin antibodies (ACLa). Recurrent pregnancy loss (RPL) is the commonest pregnancy morbidity related to this condition. The syndrome is defined by the occurrence of venous and arterial thromboses and pregnancy morbidities, in the presence of anti phospholipid antibodies (aPA), namely LAC, ACLa and anti- 2 glycoprotein I ( 2GPI) antibodies.