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Non-nucleoside reverse transcriptase inhibitors (NNRTI) has a definitive role and most commonly used in treatment of HIV infection. NNRTI act by binding to specific binding site (non-nucleoside binding pocket-NNBP) in reverse transcriptase (RT) enzyme. With the objective of developing efficient NNRTI, we have designed various Isatin analogs for effective treatment of AIDS and were subjected to molecular docking studies on five different crystal structures of RT complexed with five different ligands Nevirapine, Delaviridine, Efavirenz, Etravirine, and Rilpivirine. Combined dock-score of...

The mini sprinkler method of irrigation is recently introduced pressurized irrigation method. The basic objective of mini sprinkler is to simulate rainfall and to apply uniform water to crop. The performance of mini-sprinkler is judged by its uniformity of distribution of water which depends on the proper, efficient and economic design of the system. The important parameter in mini sprinkler irrigation is to optimize the spacing between mini sprinklers for different crops which influences the discharge, uniformity and cost. Considering the aspects and complexity in the management of mini...