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Biotransformation (metabolism) and interaction of drugs are the important factors in the establishment of therapeutic efficacy and safety. Knowledge on the enzymes responsible for drug metabolism is essential to assess the pharmacological effect and safety of a drug. Presence of CYP's and monooxygenases in microorganisms especially fungi is well documented and the use of microbial models may constitute an alternative or at least a complement to the use of animal and other systems, provided they can mimic the mammalian metabolism and afford any relevant information about the metabolism of the...

Dipeptidyl peptidase-IV inhibitors, also commonly called gliptins, are a relatively novel class of drugs for the treatment of type 2 diabetes. Various analytical methods are available for the determination of gliptins in bulk drugs, pharmaceutical formulations and biological fluids. Numerous analytical procedures including chromatographic, spectrometric and electrophoretic techniques were reported and there is a great need to review the analytical work reported so far in the literature. The present book provides a brief overview of an assortment of validated analytical methods for the...