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The micronucleus test (MNT) on mammalian bone marrow is widely accepted as a toxicological screening test used as a sensitive method for measuring genetic damage. The aim of the current study was to evaluate frequency of micronucleated polychromatic erythrocytes in the bone marrow of mice treated with 2-Deoxy -D- Glucose (2DG) and cyclophosphamide (CPH). The mean MnPCE values are found a significant inhibition in micronuclei formation was noticed with Cyclophosphamide 125 mg/kg body weight dose (p > 0.001) to compare with 2 DG and control groups. When we use 2-DG in the MN analysis, it was...

Coronary artery disease (CAD) is one of the major health problems responsible for increasing mortality and morbidity all over the world. The hypothesis of the study is that elevated levels of antioxidant enzymes are associated with increased stable coronary artery disease. With this perspective in the study, the role of trace elements, lipids and antioxidant enzymes levels in the serum of patients with CAD were determined and the presence of DNA damage in peripheral blood lymphocytes in these patients was also verified. Our findings reports that the increased DNA damages are found in CAD...

Coronary artery disease (CAD) is a narrowing of the small blood vessels that supply blood and oxygen to the heart. CAD is the most common form of heart disease in the Western world and is one of the leading causes of death in the United States. In addition to lifestyle and environmental factors which are major aetiologic determinants, there is considerable familial clustering of the disease indicating a genetic component in its causation. Although the total genetic contribution to CAD risk can be quantified, the determination of the size and number of contributing effects is impossible...