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This book was written by Valerii Leonov, Director of the Academy of Sciences in St.Petersburg. In February 1988 the Academy of Sciences was hit by the worst library fire of the century. Using memoirs, documents, newspaper reports and the personal testimony of those involved, Leonov has meticulously reconstructed events surrounding the fire, the huge clean-up operation and the climate of mistrust and back-stabbing which developed amongst library staff in the wake of the disaster. These events culminated in an accusation of illegalities levelled at Leonov himself, a charge of which he has since...

Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors many years of experience in academia and the pharmaceutical industry.

While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian...