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These lecture notes are based on the theory of experimental design for courses given by Valerii Fedorov at a number of places, most recently at the University of Minnesota, the Vienna of University, and the University of Economics and Business Administra tion in Vienna. It was Peter Hackl's idea to publish these lecture notes and he took the lead in preparing and developing the text. The work continued longer than we expected, and we realized that a few thousand miles distance remains a serious hurdle even in the age of Internet and many electronic gadgets. While we mainly target graduate...

Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors many years of experience in academia and the pharmaceutical industry.

While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian...