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Sickle cell anemia is one of the major hereditary health problem in tropical Africa where the sickle cell gene frequency is particularly high. The disease occurs with high incidence in west,east and central Africa and this has been related to the prevalence of malaria in these regions. The classic hallmark of sickle cell anemia are episodes of vaso-occlusive crisis often with multiorgan manifestation and chronic haemolytic anemia. vaso-occlusive crisis is the most common cause of hospitalization in sickle cell disease. It affects the growth and academic performance of individual. Thus it...

Thrombocytopenia is platelet count <1.5 x105/µl and is one of the commonest cause of bleeding. Though not a disease, but it is a consequence of many disease processes. It is a common manifestation of a spectrum of diseases, some of which are reversible, like megaloblastic anaemia, to diseases with fatal outcome like acute leukemia & multiple myeloma.The Preventable causes of thrombocytopenia like infections & anaemia are present in high percentage. Hence most of cases of thrombocytopenia have a favorable prognosis. This work, is about the various causes of thrombocytopenia, its...