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Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.

• Extended timely reviews of topics in medicinal chemistry
• Targets and technologies relevant to the discovery of tomorrow's drugs
• Analyses of successful...

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

*Presents the latest research in the field of drug discovery *Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect

A quartet's heist built on vengeance is detoured by greed, love, murder, and ulterior motives.

Topeka, Kansas is home to the Zved's, a notorious group of wealthy hitmen who aren't afraid to make bold moves if it means saving themselves. Billy Lewis, a local cop working for his father, knows that first hand. After his father is killed, Billy is forced to take the reins of caring for his well-meaning but mentally unstable brother, Frank. When Billy stumbles upon Alicia Diaz - a mysterious, benevolent, and beautiful Cuban immigrant - they join forces to conspire to steal enough money...

Have you ever felt like you're not in control? That you're a victim of circumstance, or of your partner or family or boss? That your 'karma' is catching up with you, or even that you have a 'life plan' that involves suffering? But what if you're actually in control as you create your reality afresh in each moment? * Even if your greater self chooses certain circumstances in your life... you still create your reaction to them. * Time isn't continuous, so the 'past' has no bearing on the present... unless you let it. * Physical reality is nothing more than a mirror... it only reflects what you...

A home invasion uncovers a conspiracy that threatens to overthrow a nationwide criminal enterprise.

For Marco Salazar, it was supposed to be a routine home invasion. Except, as he learned, there's no such thing. With the help of his longtime friend, Antonio Esposito - the soft-spoken wingman - and his pizzeria-owning uncle, Amelio "Big Sal," Marco's journey for righteousness for his falsely imprisoned father, Bartolo, leads them through the suburbs of Boston. A string of home invasions leaves the trio just shy of having the money needed for Bartolo's defense attorney's retainer, and...

This volume provides reviews of six topics demonstrating the breadth of the field and recent successes in medicinal chemistry. Each of the first five chapters takes an important biochemical target as its theme and provides an insight into current progress in drug design. The last chapter focuses on the vital subject of pharmacokinetics and the great strides that have been made in this discipline during the past decade. All chapters provide an insight into the skills required of the modern medicinal chemist, in particular, the use of an appropriate selection of the wide range of tools now...

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.

• Extended timely reviews of topics in medicinal chemistry
• Targets and technologies relevant to the discovery of tomorrow's drugs
• Analyses of...

This two-volume work describes the early history of mechanical engineering from prehistory, when mining and agriculture first appear, to the beginnings of industrialisation. The old definition that if it moves it's mechanical is used and consequently the books are divided into four major sections: power generation and transport in the first volume; manufacturing technology and weapons technology in the second volume. Background chapters to each section broadens the text and depth is added by analytical appendices describing the principles of operation, optimum operating conditions, and...