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The Ca+2-dependent mammalian Proprotein Convertase Subtilisin Kexins (PCSKs) or Proprotein/ Prohormone Convertases (PCs) are a family of endoproteases that play critical roles not only in normal development and metabolism but also in various physiological and pathological conditions. These were initiated by the proteolytic processing of large inactive proproteins into their shorter bioactive mature forms by the PCSK enzymes. These events take place in a highly selective, orchestrated, and stepwise manner. Among the various proprotein substrates of PCSK enzymes, particularly important are the...

Viscosity and thermal conductivity are two temperature dependent properties of matter. In most of the problems of fluid mechanics, the viscosity and thermal conductivity of the fluid were assumed to constant. However it is known that these physical properties can change significantly with temperature.When the effect of variable viscosity and thermal conductivity are taken in to account, the flow characteristics are substantially changed from that of constant cases. Most fluids however have temperature dependent properties, and under circumstances where large temperature gradients exist...