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Examines America's experience with a wide range of quarantine practices over the past 400 years and the political, economic, immigration, and public health considerations that have prompted success or failure within the evolving role of public health. The novel strain of coronavirus that emerged in late 2019 and became a worldwide pandemic in 2020 is only one of more than 87 new or emerging pathogens discovered since 1980 that have posed a risk to public health. While many may consider quarantine an antiquated practice, it is often one of the only defenses against new and dangerous...