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In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, and amphetamine, as well as legal drugs such as nicotine and alcohol. We also understand the main components of a 'reward system' and its connections to major brain regions involved in motivation and emotion, such as the amygdala, hippocampus, and prefrontal cortex. The Neurobiology of Addiction describes...

In recent years there have been major advances in areas of clinical neuroscience including neurogenetics, neuroimaging and the scientific study of consciousness. Disorders of Brain and Mind II brings together the most important findings since the previous volume was published in 1998. Imaging of the normal and abnormal mind figures prominently, and there is coverage of genes and behavior, brain development, consciousness and aggression. New disease-oriented chapters detail recent advances in dementia, affective illness and drug use and abuse. Clinical chapters are paired with those describing...

A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.