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This book gives a broad and authoritative overview of research currently underway in the fields of optical science and engineering throughout the world. The contributions, which are written by internationally renowned scientists, are of particular interest to specialists and nonspecialists in the many disciplines covered. They are less formal than the standard technical reviews found in academic journals and this is what makes the book accessible to readers who are not specialists in optical science and engineering.

This book focuses on group sequential methods for clinical trials with co-primary endpoints based on the decision-making frameworks for: (1) rejecting the null hypothesis (stopping for efficacy), (2) rejecting the alternative hypothesis (stopping for futility), and (3) rejecting the null or alternative hypothesis (stopping for either futility or efficacy), where the trial is designed to evaluate whether the intervention is superior to the control on all endpoints. For assessing futility, there are two fundamental approaches, i.e., the decision to stop for futility based on the conditional...