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L'immunothA(c)rapie est une approche attractive pour le traitement des cancers, en particulier le mA(c)lanome. Des A(c)tudes prA(c)-cliniques dA(c)pendent normalement de modA]les oA des cellules tumorales cultivA(c)es in vitro sont injectA(c)es dans des souris syngA(c)niques. Cependant, ces modA]les ne rA(c)capitulent pas les interactions hAte-tumeur de long terme. Notre modA]le de mA(c)lanome inductible, se rapproche plus de ce qui se passe chez le patient. Suite A un traitement par 4-hydroxy-tamoxifA]ne, la recombinase Cre est activA(c)e et induit la perte du gA]ne Ink4a/Arf et l'activation...

Climate change poses multiple challenges to development. It affects lives and livelihoods, infrastructure and institutions, as well as beliefs, cultures and identities. There is a growing recognition that the social dimensions of vulnerability and adaptation now need to move to the forefront of development policies and practices.

This book presents case studies showing that climate change is as much a problem of development as for development, with many of the risks closely linked to past, present and future development pathways. Development policies and practices can...

Climate change poses multiple challenges to development. It affects lives and livelihoods, infrastructure and institutions, as well as beliefs, cultures and identities. There is a growing recognition that the social dimensions of vulnerability and adaptation now need to move to the forefront of development policies and practices.

This book presents case studies showing that climate change is as much a problem of development as for development, with many of the risks closely linked to past, present and future development pathways. Development policies and practices can...