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Oxidative stress is one of the major symptoms accompanying physiological functions and numerous diseases. Oxidants and free radicals are connected with diseases such as cancer, diabetes, infectious, cardiovascular and neurodegenerative diseases and also in the aging process itself. Therefore, comprehensive knowledge of the underlying mechanisms of oxidant and free radical production and the defence against this permanent threat to cells is important for the understanding of many physiological and pathophysiological processes. This book overviews the basic mechanisms of oxidant formation and...

This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease.

• Contributions from leading authorities
• Informs and updates on all the latest developments in the field

​Das Essential behandelt in leicht verstandlicher, komprimierter Weise die Grundlagen altersbedingter Zellveranderungen, die unter Umstanden zur Neurodegeneration fuhren konnen. Der Autor erlautert, wie der Alterungsprozess und die Neurodegeneration durch oxidativen Stress und dabei entstehende Schaden beeinflusst werden. Unter diesen Schaden nimmt die Bildung von Proteinaggregaten, die hier besonders ausfuhrlich beschrieben werden, eine Schlusselstellung ein. Daruber hinaus werden einige Aspekte der Ernahrung im Alter und ihre moglichen Auswirkungen auf die Entstehung von...

Oxidative stress is one of the major symptoms accompanying physiological functions and numerous diseases. Oxidants and free radicals are connected with diseases such as cancer, diabetes, infectious, cardiovascular and neurodegenerative diseases and also in the aging process itself. Therefore, comprehensive knowledge of the underlying mechanisms of oxidant and free radical production and the defence against this permanent threat to cells is important for the understanding of many physiological and pathophysiological processes. This book overviews the basic mechanisms of oxidant formation and...

Reviews our current understanding of the role of protein oxidation in aging and age-related diseases

Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation...