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Excessive ethanol consumption causes liver injury, resulting in steatosis (fatty liver), alcoholic hepatitis, fibrosis, and ultimately cirrhosis. About 15% of alcoholics develop cirrhosis, this particular liver disease is normally irreversible. However, alcoholic fatty liver and, alcoholic hepatitis can be reversed. Ethanol-induced liver injury is, in part, caused by oxidative stress resulting from enhanced oxidant formation. One oxidant, peroxynitrite (PN), is a by-product of ethanol metabolism and is generated by the induction of nitric oxide synthase. This leads to the increased generation...