Mitochondria imaging of two-photon absorption molecule containing amin

ISBN-13: 9783659961540 / Angielski / Miękka / 2016 / 52 str.

Qiong Zhang; Tian Yupeng

Opis

Two-photon fluorescent probes have emerged as promising molecular tools for imaging subcellular organelles. Here, the facile synthesis of three novel nitro molecules (Z1-Z3) with lager two-photon absorption cross-section and three novel amino molecules (L1-L3) based on mitochondrial probes with two-photon absorption are presented. Their photophysical properties have been investigated both experimentally and theoretically. The study of nonlinear optical property revealed that Z1-Z3 possess more excellent two-photon absorption (2PA) cross-section values than L1-L3 and the 2PA cross-section values were enhanced with increasing electron-donating strength of the end group when fixed the opposite group (nitro or amino). Furthermore, in consideration of the water solubility and fluorescent intensity, L1-L3 possessing high specificity for mitochondrial localization were applied to biology, which is advantageous in comparison with commercially available mitochondrial trackers. Due to their low cytotoxicity, these small molecules L1-L3 offer a promising platform to directly monitor mitochondria in living cells and zebra fish.

O autorze

Qiong Zhang received her PH.D. degree in inorganic chemistry from Department of Chemistry in Anhui University in 2014 under the supervision of Prof. Yupeng Tian. Her current research focuses on Two-Photon Absorption (TPA) materials and their biological applications, as well as TPA metal ion sensors.