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Prince George E. Lvov was born in Dresden in 1861, the same year Tsar Alexander II emancipated the serfs and Russia began to move away from its static society of orders toward a more modern polity. He died in exile in Paris in 1925 with Russia once again in thralldom. Prince L'vov dedicated his life to the improvement of the peasantry's condition and, like many other liberals, hoped to acculturate them to the norms and values of a civil society to attempt to overcome the backwardness of provincial life and ultimately to integrate them as 'citizens" into a modern, vibrant "nation." L'vov...

Despite the large U.S. investment in health science, and the vast and growing body of peer-reviewed research findings it has produced, a compelling body of evidence suggests that research too often has been slow, inefficient, and fallen short of desired impacts on health. A key question is how research might be changed to be more innovative, less wasteful, and more responsive to unmet health needs.One emerging response within clinical and translational science is to advance an approach that attempts to close the gap between research scientists and key stakeholders; the individuals and groups...