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Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. The book discusses potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of the drug discovery process. This comprehensive reference describes procedures to recognize common targets in various bacterial species for the design of broad-spectrum antibiotics and clearly...

Through the smoke-lit pool halls, back roads, rehab centers, truck stops, and diners of the still industrial world, Sean Thomas Dougherty offers us the stories he has lived and collected of men and women barely working, just getting by, but every morning still going on, even if unsure.

Unsung unbearably blue, even frightening

in how they leave us, our responsibilities

among the debris, these utterances

we cannot hold.

Sean Thomas Dougherty is the author of nine books including Nightshift Belonging to Lorca, a finalist...

Originally published in 1963, this classic book is a rethinking of the history of Western political philosophy. Charles N. R. McCoy contrasts classical-medieval principles against the "hypotheses" at the root of modern liberalism and modern conservativism.

In Part I, "The Classical Christian Tradition from Plato to Aquinas," the author lays the foundation for a philosophical "structure" capable of producing "constitutional liberty." Part II, "The Modern Theory of Politics from Machiavelli to Marx," attempts to show, beginning with Machiavelli, the reversal and destruction of the...