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During the twentieth century, new neurobehavioral diseases appeared or were described for the first time. Exposure to certain toxins or noxious environments, for example, produced illnesses that did not exist before the twentieth century. In addition, established illnesses were reconceptualized with regard to their cause or neurobiological basis. Autism, for instance, was described for the first time during the twentieth century and may not have existed previously. Its cause was subsequently reconceptualized from a disorder related to inadequate parenting, to a brain disorder with possible...