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Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease, and rarely Charcot disease, is the most common form of motor neuron disease. It is typically characterized by degeneration of the motor neurons, and is usually fatal within a few years of onset. A subset of population suffering from ALS is due to inherited and genes mutation identified in familial cases have been involved in pathogenesis of ALS. Molecular mechanisms involved linked with SOD1-related ALS has revealed a complex array of interconnected pathological processes, including glutamate excitotoxicity, dysregulation...