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The Book contains a method for determination of some diverse valproates salts like magnesium valproate, sodium valproate, lithium valproate, calcium valproate and its Pharmacopeial impurities in bulk drug and in dosage form. It illustrates the method for magnesium valproate and its process related impurities and the same is applicable for the other biologically significant salts of valproic acid. In addition to this, it also confirms that the same is applicable for determination of active content in pharmaceutical dosage form.

Valproic acid is chemically known as 2-propylpentanoic acid.Valproic acid (VPA) is a chemical compound that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and less commonly, it is also used to treat migraine headaches and schizophrenia.A selective ultraperformance liquid chromatographic (UPLC) method for the quantification of valproic acid and its known related impurities using ion pair reagent has been developed

Aripiprazole is chemically known as7- 4- 4-(2, 3-dichlorophenyl) piperazin-1-yl] butoxy]-3, 4-dihydro-1H-quinolin-2-one, is an atypical antipsychotic and anti depressant used in the treatment of schizophrenia, bipolar disorder, and clinical depression. Chromatographic Condition has developed for the analysis of Aripiprazole in bulk and Pharmaceutical dosage form, force degradation (alkali, acidic, thermal, photolytic and oxidative condition) is also applied to the drug which confirms method as a stability indication method.

Alpha keto-analogues of valine, leucine, isoleucine, methionine, phenyl-alanine, and (in one instance) tryptophan and histidine, along with the remaining essential amino acids, are used to treat severe renal failure (Chronic Uremia). Mixtures of the salts are useful in the treatment of renal and hepatic disorders characterized by protein intolerance leading to deficiencies of various essential and semi-essential amino acids in the body. The analytical method for determination of calcium salts of some alpha keto acid analogues using ultra performance liquid chromatography was developed and...