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Contemporary Pediatric Hematology and Oncology covers many aspects of research and patient management within the area of blood disorders and malignant diseases in children. Blood diseases are a distinctive group of inherited and acquired, benign and malignant, acute and chronic disorders with diverse incidence, etiology, pathogenesis, and prognosis. Of interest are clinical studies as well as basic and translational research reports regarding pathogenesis, genetics, molecular diagnostics, pharmacology, molecular targeting, standard and novel therapies for the most common blood disorders, and...

Iron is an essential element for numerous fundamental biologic processes. Iron-containing proteins are required for vital cellular and organismal functions including oxygen transport, mitochondrial respiration, intermediary and xenobiotic metabolism, nucleic acid replication and repair, host defense, and cell signaling. However, excess iron is toxic. This book provides a comprehensive overview of the essential role of iron in biology, the regulation of systemic and cellular iron homeostasis, and how imbalances in iron homeostasis contribute to disease.