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Recent progress in bioinformatics and especially high-throughput sequencing has enabled us to sequence and analyze genomes of many individuals, which can lead to improved diagnostics and treatment for patients suffering from genetic diseases. To achieve this, tools used in both clinical and research environments need to be enhanced to handle large amounts of data. This book analyzes application-level parallelization of database query processing by means of sharding as a technique for improving performance and scalability of an open-source search engine for genomic variants. We describe the...