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Is there a point at which medical intervention becomes counter productive? This work is an examination of this concept, contending that as health policies increasing shift towards evidence-based and guideline-driven practice they risk losing sight of the complexities and ambiguities inherent to human physiology and patients' lives. Heuristics and cultural constructs ("more is better") are all too often confused with science - leading to expensive, ineffective health care. Using a single concept, therapeutic equivalence, this interdisciplinary analysis covers the trajectory of modern medicine...