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This book presents a comprehensive analysis of the application of gene therapy in dentistry. Gene therapy offers a paradigm shift by addressing oral diseases at the molecular level, aiming for preventive and regenerative outcomes. This book explores the multifactorial etiology of periodontitis, integrating microbial, environmental, genetic, and immunological components. Multiple disease progression models like the linear, burst, and dysbiosis based are reviewed to elucidate clinical variability. A detailed examination of genetic polymorphisms (eg, IL-1, IL-6, TNF- ) illustrates host...