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The present study serve to extend the growing number of earlier investigations on therapeutic products from freshwater and marine sources as potent antineoplastic agents and confirm that both squid ink extract and freshwater mussel extract of C. aegyptiaca decreased lipid peroxidation, improved antioxidant status, and thereby act as a potential therapeutic complement in the treatment of different pathologies that may be related to an imbalance of the cellular oxidoreductive status associated with liver injury following tumor inoculation.