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Many children admitted to the pediatric intensive care unit (PICU) are admitted with serious infections. If they do not have serious infections prior to admission, there is also a high chance of them acquiring nosocomial infection once admitted. Many syndromes may lead to serious infection and the need for high dependency or intensive care. In addition, the numbers of children who are severely immunocompromised and surviving for extended periods are increasing. Any delay in therapy may produce more severe infection in an immunocompetent patient. As the influence of genetic factors in...