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By the time William Penn was planning the colony that would come to be called Pennsylvania, with Philadelphia at its heart, Europeans on both sides of the ocean had long experience with the hazards of city life, disease the most terrifying among them. Drawing from those experiences, colonists hoped to create new urban forms that combined the commercial advantages of a seaport with the health benefits of the country. The Contagious City details how early Americans struggled to preserve their collective health against both the strange new perils of the colonial environment and the...