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Modification of the structure of a known drug is one way to develop new drugs. For this purpose, we have optimized the pyrimidobenzimidazole derivatives using molecular modeling studies. QSAR analysis has been carried out on a series of pyrimidobenzimidazole derivatives using the physicochemical parameter and molecular descriptors. The database was subjected to QSAR studies using Chemsketch software version 10.0 and all the parameter & descriptors were calculated using TSAR 3D version 3.3 for windows. The regression analysis has shown that SFI (Shape flexibility index), R (Randic index), B...

The World Health Organization (WHO) estimates that 80% of the world's population presently uses herbal medicine for some aspect of primary health care. The use of, and search for, drugs and dietary supplements derived from plants have accelerated. In the recent years, the interest in medicinal plants has increased in a great deal. People have also taken this matter seriously by conducting various researches on plant based medicine which produces no side effect. In continuation of our efforts in search of potential antimicrobial and antioxidant agent we have taken a new sepecies of Ipomoea...

Inflammatory diseases and cancer are serious health problems for mankind. Many antiinflammatory and a few anticancer drugs are available in the market. Most of the drugs used clinically have serious side effects and hence there is a development of safer antiinflammatory and more active anticancer drugs. In continuation of our work in this direction, we have synthesized a number of pyridine, pyrazine, pyrimidine, pyrimidobenzimidazole, hemin & hematoporphyrin derivatives and evaluated them for their antiinflammatory, analgesics and/or anticancer activities. A few of them are very potent...