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Shane Crotty's biography of David Baltimore details the life and work of one of the most brilliant, powerful, and controversial scientists of our time. Although only in his early sixties, Baltimore has made major discoveries in molecular biology, established the prestigious Whitehead Institute at MIT, been president of Rockefeller University, won the Nobel Prize, and been vilified by detractors in one of the most scandalous and protracted investigations of scientific fraud ever. He is now president of Caltech and a leader in the search for an AIDS vaccine. Crotty not only tells the compelling...

The adaptive immune system ensures that our bodies remember pathogens so that we can rapidly mount an immune response if they are encountered again, without succumbing to infection. This volume examines the basis of this immune memory and the roles of the T and B cells involved.

Topics covered in this essential volume include:
- Do memory CD4 T cells keep their cell type programming: Plasticity versus fate commitment?
- Is it possible to develop a "universal" influenza vaccine?
- What is the value of animal models in predicting vaccine efficacy in humans?
- Is a human CD8 T...