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Drug delivery by injecting them through arteries poses unique challenges. The first attempts to treat malignant brain tumors by arterial injections were undertaken soon after World War II. Yet, the applications of arterial delivery in treating neurological diseases have not advanced significantly over the last seventy years. Although arterial drug delivery is used to treat several neurological conditions, its applications, other than for localization of brain functions, remain experimental and are unproven in robust scientific studies. Over the last two decades, interventional radiology has...