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The aim of study was to Design and Evaluation of Miconazole Nitrate Microsponge for Sustained Release Topical Drug Delivery System by Quasi-Emulsion Solvent diffusion Method. The average size of microsponge formulation is less than 300um. So it has good patient compliance. Microsponge formulation has ability to improve bioavailability & solubility of poorly soluble drug. The Miconazole Nitrate microsponge were prepared by using Eudragit RS100 as a polymer, PVA as an emulsifying agent, TEC as a plasticizer, DCM and methanol used as solvent. Optimization of Microsponge was done by using Central...

To develop & validate UV & HPLC methods for simultaneous estimation of Cefpodoxime Proxetil & Levofloxacin Hemihydrate in bulk drug and pharmaceutical dosage form.By application of analytical tequniques like various UV methods and HPLC for simultaneous estimation of CPD& LVX like Simultaneous equation method, Q-absorbance ratio method, First order derivative method and RP-HPLC method. Developed methods were applied to perform analysis of marketed formulation (Glevopod). Validation of developed methods was performed according to ICH Q2 (R1) guideline. Comparison of all developed and validated...