Reactivity of cyclododecanone in aldol and Mannich-Type reactions : Direct anti & regio-specific aldol, Mukaiyama aldol and Mannich-type reactions in zwitter ionic stabilized CDD & lactams

ISBN-13: 9783659765001 / Angielski / Miękka / 2016 / 292 str.

Sathesh Venkatesan; Sathiyanarayanan Kulathu Iyer

Opis

In this book we address, cyclododecanone as a substrate-controlled precursor. Its, unique activation strategy, acting cooperatively with Lewis based or Lewis acid groups, has been applied to the development of a novel generation of cyclododecanone based compounds. The viability of the catalyst under optimized reaction condition was established for all the title reactions. Extended mechanistic pathways lead to the suggestion of a catalytic cycle in which highly preferred transition state plays a major role for both yield and diastereoselectivity for the reactions. Finally, strategies were employed to further examine asymmetric induction reaction in cyclododecanone using proline as a catalyst, but we could not achieve goals at present conditions. Even unmodified ketone like propiophenone the stereochemistry has been thoroughly investigated. Whereas, higher cyclic ketones like 9-12 membered ring cyclic ketones the stereochemistry has not been studied so far. The aim of our work is to studied the reactivity of CDD in aldol sequences and Mannich-type reaction in direct manner and to know the stereochemical behavior of higher ring ketones.

O autorze

Sathesh Venkatesan was born in Vellore, India. Where he is lived in Palappadi village. He received his undergraduate degree in Chemistry at Muthurangam Govt. Arts College, Vellore. After a brief stint in the chemistry postgraduate program & doctoral studies at VIT University under the direction of Professor Dr. K. Sathiyanarayanan.