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The book describes a protocol to evaluate anti-inflammatory activity in popular animal models along with biochemical and molecular pharmacological investigations. The present work evaluated the anti-inflammatory and antioxidant activity of the methanol extract of Ruta graveolens leaves (RG-M) in various in vivo and in vitro models. For the anti-inflammatory activity evaluation, RG-M was administered by the oral route (p.o.) in carrageenan-induced paw edema model and by the intraperitoneal route (i.p.) in exudative inflammation model. In vitro inhibition of cyclooxygenase and lipoxygenase...

The present book presented the various models of hepatoprotective screening as well as a study aimed at describing the investigation of the antioxidant and hepatoprotective activity of methanolic flower extract of Nerium oleander. In vitro antioxidant activity MENO-F was evaluated by various assays, including reducing power, lipid peroxidation, DPPH, ABTS, superoxide anion, hydroxyl radicals and metal chelation. The hepatoprotective and in vivo antioxidant activity of MENO-F were evaluated against CCl4-induced hepatic damage in rats. The extract showed potent activities on reducing power,...