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The present investigation aimed at formulation, and evaluation of vesicular drug carrier system liquid crystalline proliposomes for transdermal delivery of antifungal agent, griseofulvin. Liquid crystalline proliposomal gel (LCPG) formulations of griseofulvin were prepared, and characterized for vesicles shape, size, entrapment efficiency, and drug permeation across pig ear skin. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized LCPG formulation showed enhanced In Vitro skin...