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Liver transplantation remains the only definitive treatment for patients with end stage liver disease. In this study the proliferative activity of hepatocytes and lymphocytes were investigated in liver biopsies of post-transplant patients with acute and chronic rejection as well as recurrent hepatitis C. A higher proliferation rates of hepatocytes and lymphocytes were seen in allograft rejection cases suggesting a in situ source of activation and priming of lymphocytes. The utility of ki-67 proliferation marker in differentiating recurrent HCV from acute rejection was also investigated....

It is clear now that viral hepatitis C (HCV) is a major health problem. The magnitude of the problem is quite high in Egypt being declared as having the world's highest prevalence of HCV infection. This book addresses various aspects of HCV with emphasis on its prevalence in Egypt, therapeutic measures and features of post-transplant recurrence. As available therapeutic measures a re lengthy and fraught with complications and side effects, the choice of patients plays a major role in reaching highest levels of success. Hence, predictive factors of a beneficial response were also highlighted.