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Mucoadhesive systems are those which bind to gastric epithelial cell surface or mucin and serve as a potential means of extending GRT of drug delivery system in the stomach by increasing the duration of contact of drug with the biological membrane. Mucoadhesive microspheres include microparticles and microcapsules (having a core of the drug) of 1-1000nm in diameter and consisting either entirely of a mucoadhesive polymer or having an outer coating of it,respectively.All duodenal ulcers and most gastric ulcers caused by H.Pylori acid inhibition with antibiotic treatment is highly...

The objective of the study was to develop smotically driven oral drug delivery system of Aceclofenac, to be taken twice daily. It is also objective of present study to evaluate developed osmotic pump. Sodium chloride & sodium bicarbonate were used as an osmogent. The tablets were coated with cellulose acetate as the semipermeable membrane containing castor oil as a plasticizer and microporous membrane was developed by using polyethylene glycol as a plasticizer and pore forming agent.The emipermiable membrane formed by using cellulose acetate as a polymer and castor oil as a plasticizer,...