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Paracetamol is one of the most commonly used drugs worldwide and it even has severe hepato-toxic effects in long term use i.e. chronic use. Our present work was aimed at reducing this toxicity by using some natural products since naturally obtained products have minimal toxic effects than synthetic ones. Terminalia chebula leaf powder was prepared and fed to rats who were receiving paracetamol and it showed promising results in countering paracetamol toxicity

This work was conducted to study oral acute toxicity study of Phyllanthus acidus leaves and its action on the central nervous system (CNS) because no data in the literature have been found about of pharmacological activity of this plant in the CNS. In the present study aqueous extract of phyllanthus acidus leaves (Phyllanthaceae) was tested orally in swiss albino mice at doses of 100 mg/kg, 200 mg/kg and 400 mg/kg b.w. For CNS related activities significant central nociceptive activity was observed.