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The main objective of the research is to design an active thiol substituted oxadiazole inhibitor against GlmS receptor of gram-negative and gram-positive bacteria with in silico and in vitro antibacterial approaches. A scaffold of 1,3,4-oxadiazole was designed and the synthetic feasibility to attain the scaffold. PyRx software was used. The ligand poses with the least free energy. ADMET studies were conducted. The synthesis steps included 4 different reactions. Substituted carboxylic acids were used as the starting reagent. All of the reactions were monitored by TLC. Synthesized compounds...