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This book is a collection of preclinical and clinical reports on the appli- cation of gene therapy to human disease. The focus of these studies is on cancer and cardiovascular disease. There are two fundamental technologies for delivering therapeutic genes to diseased ceHs: either viral vectors, as discussed by Dr. Bal- main, or non-viral vector systems, as discussed by Dr. Felgner. The strengths and limitations of each of these delivery systems are charac- terized. The use of a therapeutic gene to treat a disease has taken two general approaches. The first is to introduce anormal (i. e. ,...