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Comprehensive and state of the art, the second edition of Pharmacotherapy of Depression offers major revisions of every chapter and the addition of new chapters by expert contributors. The first chapter reviews the neurobiology of depression, which lays the groundwork for understanding the mechanisms of action of antidepressants. In the next chapter, a review of the general principles guiding the diagnosis and medication treatment of unipolar depression is provided. The clinical pharmacology of antidepressants is reviewed in some detail, supplemented by tables that provide information on...

The large and diffuse body of literature connected with sign-solvability is presented as a coherent whole for the first time in this book.

Comprehensive and state of the art, the second edition of Pharmacotherapy of Depression offers major revisions of every chapter and the addition of new chapters by expert contributors. The first chapter reviews the neurobiology of depression, which lays the groundwork for understanding the mechanisms of action of antidepressants. In the next chapter, a review of the general principles guiding the diagnosis and medication treatment of unipolar depression is provided. The clinical pharmacology of antidepressants is reviewed in some detail, supplemented by tables that provide information on...

In a sign-solvable linear system, the signs of the coefficients determine the signs of some entries in the solution. This type of system is part of a larger study that helps researchers understand if properties of a matrix can be determined from combinatorial arrangements of its elements. In this book, the authors present the diffuse body of literature on sign-solvability as a coherent whole for the first time, giving many new results and proofs and establishing many new connections. Brualdi and Shader describe and comment on algorithms implicit in many of the proofs and their complexity. The...